Ambitions and vision

Menarini Silicon Biosystems, a subsidiary of the Menarini Group, specializes in advanced technologies for isolating and analyzing rare cells with high precision, primarily for clinical research in oncology. Their flagship products, the DEPArray and CELLSEARCH systems, allow for the precise identification, recovery, and molecular analysis of individual cells from complex biological samples. These platforms support research in areas such as cancer diagnostics and liquid biopsy, offering tools that can capture circulating tumor cells and other rare cell types from blood and tissue samples for detailed genetic analysis. Menarini Silicon Biosystems is considered best in class for circulating tumor cells (CTC) testing primarily due to their CELLSEARCH® system, which is the only FDA-cleared system for CTC testing that is clinically validated to prognosticate survival in patients with metastatic breast, prostate, and colorectal cancers. CELLSEARCH® is distinguished by its ability to reliably and reproducibly capture and quantify CTCs from a blood sample, which can then be used to help assess a patient's prognosis and guide treatment decisions. The company places a strong emphasis on innovation, precision, and quality in developing its cell-based diagnostic solutions. Their core values highlight a commitment to scientific advancement and client-focused solutions in the biotechnology sector. .  

Technical fields

Menarini Silicon Biosystems offers specialized products and services that focus on the identification and analysis of rare cells for clinical research, particularly in the field of oncology. The CELLSEARCH® system works by targeting cells that express the EpCAM antigen, a common marker found on most epithelial cancer cells, using ferrofluid nanoparticles coated with specific antibodies. Once captured, these cells are stained and identified using proprietary imaging software, allowing for the enumeration and characterization of CTCs. They alsy offer DEPArray™ Technology which is a digital sorting platform that allows for the isolation and analysis of rare cells with single-cell precision. DEPArray™ is capable of analyzing cellular morphology and molecular characteristics, facilitating the study of complex heterogeneous samples. They offer the Ampli1™ WGA Kit for whole genome amplification of DNA from single cells, enabling detailed genetic analysis following cell isolation with technologies like DEPArray™; the Ampli1™ LowPass Kit is designed for low-pass genome sequencing from single cells, this kit is crucial for detecting copy number variations in isolated cells. Another one of their products is CELLMAG™ that complements CELLSEARCH® by providing additional cell isolation and purification capabilities, enhancing the downstream analysis of captured CTCs. They also offer Sample Preparation Kits for processing various sample types, including blood, tissue…